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Strawberry Decreases Intraluminal and Intestinal Wall Hydrolysis of Testosterone Undecanoate

Male hypogonadism is often treated by testosterone (T) replacement therapy such as oral administration of the ester prodrug, testosterone undecanoate (TU). However, the systemic exposure to T following oral TU is very low due to esterase-mediated metabolism, particularly in the small intestine. The...

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Principais autores: Atheer Zgair, Yousaf Dawood, Suhaib M. Ibrahem, Jong Bong Lee, Wanshan Feng, Peter M. Fischer, Pavel Gershkovich
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-01-01
Serier:Molecules
Fag:
testosterone undecanoate
FaSSIF
intestinal degradation
first-pass metabolism
strawberry
Online adgang:https://www.mdpi.com/1420-3049/26/1/233
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