Strawberry Decreases Intraluminal and Intestinal Wall Hydrolysis of Testosterone Undecanoate

Male hypogonadism is often treated by testosterone (T) replacement therapy such as oral administration of the ester prodrug, testosterone undecanoate (TU). However, the systemic exposure to T following oral TU is very low due to esterase-mediated metabolism, particularly in the small intestine. The...

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Bibliografische Detailangaben

Hauptverfasser:	Atheer Zgair, Yousaf Dawood, Suhaib M. Ibrahem, Jong Bong Lee, Wanshan Feng, Peter M. Fischer, Pavel Gershkovich
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-01-01
Schriftenreihe:	Molecules
Schlagworte:	testosterone undecanoate FaSSIF intestinal degradation first-pass metabolism strawberry
Online-Zugang:	https://www.mdpi.com/1420-3049/26/1/233
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