Extensive ribosome and RF2 rearrangements during translation termination

Protein synthesis ends when a ribosome reaches an mRNA stop codon. Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nascent protein, and then dissociate to allow ribosome recycling. To visualize termination by RF2, we resolved a cryo-EM ensemble of E. coli 70S•RF2...

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Principais autores:	Egor Svidritskiy, Gabriel Demo, Anna B Loveland, Chen Xu, Andrei A Korostelev
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2019-09-01
Serija:	eLife
Teme:	intersubunit rotation ribosome recycling release factor 2 GGQ motif rearrangement translation termination ensemble cryo-EM
Online dostop:	https://elifesciences.org/articles/46850
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