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LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by prominent degeneration of dopaminergic neurons in the substantia nigra and aggregation of the protein α-synuclein within intraneuronal inclusions known as Lewy bodies. Ninety percent of PD cases are idi...

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Principais autores: Darren M. O’Hara, Grishma Pawar, Suneil K. Kalia, Lorraine V. Kalia
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020-06-01
סדרה:Frontiers in Neuroscience
נושאים:
Parkinson’s disease
neurodegeneration
α-synuclein
LRRK2
autophagy
mitochondria
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fnins.2020.00577/full
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