Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma

Abstract Background The ligation of programmed death ligand 1 (PD-L1) on cancer cells to programmed cell death-1 (PD1) expressed on T cells is a key mechanism of immune evasion. Despite the approval of anti-PD1/PD-L1 therapy for several cancers, the limited response rate and adaptive immune resistan...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Meiwen Han, Qianting Guan, Fangfei Yan, Ming Wang, Dong Xi, Qin Ning
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2026-02-01
Цуврал:	Cell Communication and Signaling
Нөхцлүүд:	Fibrinogen-like protein 2 Programmed death ligand 1 Hepatocellular carcinoma Tumor microenvironment Immunosuppression
Онлайн хандалт:	https://doi.org/10.1186/s12964-026-02704-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!