A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA

Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible target sites for ribozymes based on the hepatitis delta virus motif. Using a quantitat...

Descrición completa

Detalles Bibliográficos

Principais autores:	Robert J Scarborough, Michel V Lévesque, Etienne Boudrias-Dalle, Ian C Chute, Sylvanne M Daniels, Rodney J Ouellette, Jean-Pierre Perreault, Anne Gatignol
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2014-01-01
Series:	Molecular Therapy: Nucleic Acids
Assuntos:	HIV-1 reverse transcriptase ribozyme short hairpin RNA viral kinetics
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2162253116303195
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!