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Discovery of a haptoglobin glycopeptides biomarker panel for early diagnosis of hepatocellular carcinoma

BackgroundThere is a need for new serum biomarkers for early detection of hepatocellular carcinoma (HCC). Haptoglobin (Hp) N-glycosylation is altered in HCC, but the diagnostic value of site-specific Hp glycobiomarkers is rarely reported. We aimed to determine the site-specific glycosylation profile...

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Autori principali: Mahdokht Kohansal-Nodehi, Magdalena Swiatek-de Lange, Konstantin Kroeniger, Vinzent Rolny, Glòria Tabarés, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Henry Lik-Yuen Chan, Holger Busskamp
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-10-01
Serie:Frontiers in Oncology
Soggetti:
haptoglobin
glycosylation
biomarker
glycoproteomics
hepatocellular carcinoma
diagnostics
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2023.1213898/full
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