7,7”-dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma

Abstract Background Medulloblastoma (MB) is the most common malignant pediatric brain cancer. Patients diagnosed with Sonic Hedgehog (SHH) MB typically exhibit highly metastatic tumors and have an unfavorable prognosis. 7,7”-Dimethoxyagastisflavone (DMGF), a biflavonoid compound, isolated from needl...

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Autors principals:	Yi-Shin Wu, Han-Huei Lin, Kuo-Sheng Wu, Yu-Ting Huang, Jia-Yun Liao, Shing-Shung Chu, Tai-Tong Wong, Chia-Ling Hsieh, Che-Chang Chang, Shian-Ying Sung, Chih-Yu Lin, Yu-Ling Lin
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Journal of Translational Medicine
Matèries:	SHH medulloblastoma 7,7"-dimethoxyagastisflavone MYCN MYBL2 Metabolism reprogramming Macrophage polarization
Accés en línia:	https://doi.org/10.1186/s12967-026-07809-8
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