7,7”-dimethoxyagastisflavone induced MYCN/MYBL2-dependent apoptosis and metabolism reprogramming in Sonic Hedgehog medulloblastoma

Abstract Background Medulloblastoma (MB) is the most common malignant pediatric brain cancer. Patients diagnosed with Sonic Hedgehog (SHH) MB typically exhibit highly metastatic tumors and have an unfavorable prognosis. 7,7”-Dimethoxyagastisflavone (DMGF), a biflavonoid compound, isolated from needl...

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Автори:	Yi-Shin Wu, Han-Huei Lin, Kuo-Sheng Wu, Yu-Ting Huang, Jia-Yun Liao, Shing-Shung Chu, Tai-Tong Wong, Chia-Ling Hsieh, Che-Chang Chang, Shian-Ying Sung, Chih-Yu Lin, Yu-Ling Lin
Формат:	Artigo
Мова:	Inglês
Опубліковано:	BMC 2026-02-01
Серія:	Journal of Translational Medicine
Предмети:	SHH medulloblastoma 7,7"-dimethoxyagastisflavone MYCN MYBL2 Metabolism reprogramming Macrophage polarization
Онлайн доступ:	https://doi.org/10.1186/s12967-026-07809-8
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