Engineering of Primary Human B cells with CRISPR/Cas9 Targeted Nuclease
Abstract B cells offer unique opportunities for gene therapy because of their ability to secrete large amounts of protein in the form of antibody and persist for the life of the organism as plasma cells. Here, we report optimized CRISPR/Cas9 based genome engineering of primary human B cells. Our pro...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2018-08-01
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| Reeks: | Scientific Reports |
| Online toegang: | https://doi.org/10.1038/s41598-018-30358-0 |
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