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Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Abstract Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with coagulopathy. As the primary components of im...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu, Ang Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2021-02-01
Schriftenreihe:Critical Care
Schlagworte:
COVID-19
Neutrophil extracellular trap
anaphylatoxin
Carboxypeptidase B
Online-Zugang:https://doi.org/10.1186/s13054-021-03482-z
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