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Lighting Up the Fire in the Microenvironment of Cold Tumors: A Major Challenge to Improve Cancer Immunotherapy

Immunotherapy includes immune checkpoint inhibitors (ICI) such as antibodies targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death protein/programmed death ligand 1 (PD-1/PD-L1) axis. Experimental and clinical evidence show that immunotherapy based on immune che...

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Principais autores: Alice Benoit, Guillaume Vogin, Caroline Duhem, Guy Berchem, Bassam Janji
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-07-01
coleção:Cells
Assuntos:
immunotherapy
immune checkpoint inhibitors
tumor microenvironment
metabolic reprogramming
hypoxia
Acesso em linha:https://www.mdpi.com/2073-4409/12/13/1787
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