Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice
SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3iEKO) with a nonletha...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
American Society for Clinical investigation
2021-07-01
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| سلاسل: | JCI Insight |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1172/jci.insight.147280 |
| الوسوم: |
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