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Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

SOCS3 is the main inhibitor of the JAK/STAT3 pathway. This pathway is activated by interleukin 6 (IL-6), a major mediator of the cytokine storm during shock. To determine its role in the vascular response to shock, we challenged mice lacking SOCS3 in the adult endothelium (SOCS3iEKO) with a nonletha...

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Principais autores: Nina Martino, Ramon Bossardi Ramos, Shuhan Lu, Kara Leyden, Lindsay Tomaszek, Sudeshna Sadhu, Gabrielle Fredman, Ariel Jaitovich, Peter A. Vincent, Alejandro P. Adam
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2021-07-01
Serier:JCI Insight
Fag:
Inflammation
Vascular biology
Online adgang:https://doi.org/10.1172/jci.insight.147280
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