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Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome

Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS patients. In contrast, genome-wide association studies in RLS patients have establi...

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Principais autores: Samantha Meneely, Mai-Lynne Dinkins, Miki Kassai, Shangru Lyu, Yuning Liu, Chien-Te Lin, Kori Brewer, Yuqing Li, Stefan Clemens
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-09-01
coleção:Frontiers in Behavioral Neuroscience
Assuntos:
RLS animal models
dopamine
D1 receptor
D3 receptor
Meis1
sensorimotor function
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00199/full
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