Generation of a comprehensive epigenomic atlas in clear cell renal cell carcinoma informs kidney cancer progression and heritability

Summary: By generating 194 epigenomic and transcriptomic datasets from 57 human tissue samples using H3K27ac and HIF2α chromatin immunoprecipitation sequencing (ChIP-seq), assay for transposase-accessible chromatin using sequencing (ATAC-seq), and RNA sequencing, we provide a comprehensive, integrat...

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Auteurs principaux:	Sarah Abou Alaiwi, Elio Adib, Ziwei Zhang, Sandor Spisak, Aurel Prosz, Paulo Cordeiro, Talal El Zarif, Zsófia Márta Sztupinszki, Amin H. Nassar, Ji-Heui Seo, Rianna Campbell, John A. Steinharter, Mitchell Machiela, Diptavo Dutta, Stephen Chanock, Mark Purdue, Mark Pomerantz, Sabina Signoretti, Zoltan Szallasi, Alexander Gusev, Sylvan C. Baca, Toni K. Choueiri, Matthew L. Freedman
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2026-02-01
Collection:	Cell Reports
Sujets:	CP: cancer CP: genomics
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S221112472600046X
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