Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC

Abstract Background Abnormal activation of NLRP3 inflammasome is related to a series of inflammatory diseases, including type 2 diabetes, gouty arthritis, non-alcoholic steatohepatitis (NASH), and neurodegenerative disorders. Therefore, targeting NLRP3 inflammasome is regarded as a potential therape...

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Detalles Bibliográficos

Principais autores:	Jia Zhao, Hongbin Liu, Zhixian Hong, Wei Luo, Wenqing Mu, Xiaorong Hou, Guang Xu, Zhie Fang, Lutong Ren, Tingting Liu, Jincai Wen, Wei Shi, Ziying Wei, Yongping Yang, Wenjun Zou, Jun Zhao, Xiaohe Xiao, Zhaofang Bai, Xiaoyan Zhan
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-07-01
Series:	Molecular Medicine
Assuntos:	Tanshinone I NLRP3 inflammasome ASC LPS-induced septic shock NASH
Acceso en liña:	https://doi.org/10.1186/s10020-023-00671-0
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