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Co-Crystal of Rosiglitazone With Berberine Ameliorates Hyperglycemia and Insulin Resistance Through the PI3K/AKT/TXNIP Pathway In Vivo and In Vitro

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by insulin resistance and hyperglycemia. This study examined the effect and elucidated the mechanism of improvement of hyperglycemia and insulin resistance by a co-crystal of rosiglitazone with berberine (RB) in...

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Auteurs principaux: Qichen He, Bo Chen, Gang Wang, Duanfang Zhou, Hongfang Zeng, Xiaoli Li, Yi Song, Xiaoping Yu, Wenxin Liang, Huiling Chen, Xu Liu, Qiuya Wu, Lihong Wu, Limei Zhang, Huizhen Li, Xiangnan Hu, Weiying Zhou
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2022-04-01
Collection:Frontiers in Pharmacology
Sujets:
co-crystal
insulin resistance
type 2 diabetes mellitus
glucolipid metabolism
KKAy mice
Accès en ligne:https://www.frontiersin.org/articles/10.3389/fphar.2022.842879/full
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