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Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model

During the last two decades, the introduction of tyrosine kinase inhibitors (TKIs) to the therapy has changed the natural history of CML but progression into accelerated and blast phase (AP/BP) occurs in 3-5% of cases, especially in patients resistant to several lines of TKIs. In TKI-refractory pati...

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Principais autores: Jusuf Imeri, Paul Marcoux, Matthias Huyghe, Christophe Desterke, Daianne Maciely Carvalho Fantacini, Frank Griscelli, Dimas T. Covas, Lucas Eduardo Botelho de Souza, Annelise Bennaceur Griscelli, Ali G. Turhan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-01-01
Serier:Frontiers in Immunology
Fag:
CAR-NK
NK92
CD25
leukemia
blast crisis CML
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1309010/full
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