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Comparative genomic mapping of the bovine Fragile Histidine Triad (<it>FHIT</it>) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles

<p>Abstract</p> <p>Background</p> <p>The Fragile Histidine Triad gene (<it>FHIT</it>) is an oncosuppressor implicated in many human cancers, including vesical tumors. <it>FHIT </it>is frequently hit by deletions caused by fragility at FRA3B, the most active of human common fragile sites, where <it>F...

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Main Authors: Boussaha Mekki, Floriot Sandrine, Iannuzzi Leopoldo, Di Meo Giulia, Roperto Franco, Russo Valeria, Roperto Sante, Guidi Elena, Uboldi Cristina, Eggen André, Ferretti Luca
Format: Artigo
Language:Inglês
Published: BMC 2006-05-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/7/123
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