Development of non-viral, ligand-dependent, EPHB4-specific chimeric antigen receptor T cells for treatment of rhabdomyosarcoma

Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand-independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabdomyosarcoma, whereas ligand-dependent stimulation...

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Autors principals:	Hiroshi Kubo, Shigeki Yagyu, Kayoko Nakamura, Kumiko Yamashima, Akimasa Tomida, Ken Kikuchi, Tomoko Iehara, Yozo Nakazawa, Hajime Hosoi
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-03-01
Col·lecció:	Molecular Therapy: Oncolytics
Matèries:	EPHB4 chimeric antigen receptor CAR-T cell therapy rhabdomyosarcoma piggyBac transposon stem cell memory-like T cells
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2372770521000334
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