Autologous antigen-presenting cells efficiently expand piggyBac transposon CAR-T cells with predominant memory phenotype

The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prevent early T cell exhaustion during expansion. Acti...

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Autors principals:	Kayoko Nakamura, Shigeki Yagyu, Shogo Hirota, Akimasa Tomida, Makoto Kondo, Tomokuni Shigeura, Aiko Hasegawa, Miyuki Tanaka, Yozo Nakazawa
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2021-06-01
Col·lecció:	Molecular Therapy: Methods & Clinical Development
Matèries:	chimeric antigen receptor T cells piggyBac transposon HER2 early T cell exhaustion T stem cell memory-like cells electroporation
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2329050121000516
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