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Entropy and Information within Intrinsically Disordered Protein Regions

Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-structure-function paradigm to IDRs and motivates the de...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Iva Pritišanac, Robert M. Vernon, Alan M. Moses, Julie D. Forman Kay
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2019-07-01
Schriftenreihe:Entropy
Schlagworte:
intrinsically disordered proteins
Shannon entropy
information theory
evolutionary conservation
conformational entropy
low-complexity sequences
liquid-liquid phase separation
post-translational modifications
conformational ensembles
biophysics
Online-Zugang:https://www.mdpi.com/1099-4300/21/7/662
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