Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer

In most human tumors, the MAPK pathway is constitutively activated. Since p90RSK is downstream of MAPK, it is often hyperactive and capable of phosphorylating oncogenic substrates. We have previously shown that p90RSK phosphorylates MDM2 at S166, promoting p53 degradation in follicular thyroid carci...

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Autors principals:	Immacolata Maietta, Eleonora Viscusi, Stefano Laudati, Giuseppe Iannaci, Antonio D’Antonio, Rosa Marina Melillo, Maria Letizia Motti, Valentina De Falco
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-09-01
Col·lecció:	Cells
Matèries:	p90RSK p53 MDM2 apoptosis tumorigenesis cell proliferation
Accés en línia:	https://www.mdpi.com/2073-4409/13/18/1546
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