Evolutionary Diversification of Host-Targeted <i>Bartonella</i> Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

Proteins containing a FIC domain catalyze AMPylation and other post-translational modifications (PTMs). In bacteria, they are typically part of FicTA toxin-antitoxin modules that control conserved biochemical processes such as topoisomerase activity, but they have also repeatedly diversified into ho...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Tilman Schirmer, Tjaart A. P. de Beer, Stefanie Tamegger, Alexander Harms, Nikolaus Dietz, David M. Dranow, Thomas E. Edwards, Peter J. Myler, Isabelle Phan, Christoph Dehio
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-07-01
Schriftenreihe:	Microorganisms
Schlagworte:	FicT/FicA toxin-antitoxin module FIC domain FIC signature loop adenylylation AMPylation de-AMPylation
Online-Zugang:	https://www.mdpi.com/2076-2607/9/8/1645
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