Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes

Summary: Perlecan (HSPG2), a heparan sulfate proteoglycan similar to agrin, is key for extracellular matrix (ECM) maturation and stabilization. Although crucial for cardiac development, its role remains elusive. We show that perlecan expression increases as cardiomyocytes mature in vivo and during h...

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Autori principali:	Benjamin B. Johnson, Marie-Victoire Cosson, Lorenza I. Tsansizi, Terri L. Holmes, Tegan Gilmore, Katherine Hampton, Ok-Ryul Song, Nguyen T.N. Vo, Aishah Nasir, Alzbeta Chabronova, Chris Denning, Mandy J. Peffers, Catherine L.R. Merry, John Whitelock, Linda Troeberg, Stuart A. Rushworth, Andreia S. Bernardo, James G.W. Smith
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-01-01
Serie:	Cell Reports
Soggetti:	CP: Developmental biology CP: Cell biology
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124723016790
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