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Structure-activity relationship study of steroidal 1,2,4,5-tetraoxane animalarials using computational procedures

A three-dimensional QSAR pharmacophore model for antimalarial activity of steroidal 1,2,4,5-tetraoxanes was developed from a set of 17 substituted antimalarial derivatives out of 27 analogues that exhibited remarkable in vitro activity (below 100 ng/mL) against sensitive and multidrug-resistant Plas...

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Autors principals: APURBA K. BHATTACHARJEE, KEITH A. CARVALHO, DEJAN OPSENICA, BOGDAN A. SOLAJA
Format: Artigo
Idioma:Inglês
Publicat: Serbian Chemical Society 2005-03-01
Col·lecció:Journal of the Serbian Chemical Society
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Accés en línia:http://www.shd.org.yu/HtDocs/SHD/vol70/No3/JSCS_V70_No3-03.pdf
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