Retinitis Pigmentosa‐Associated Gene TRIM49 Regulates ULK1‐Mediated Autophagy and Photoreceptor Phagocytosis by the Retinal Pigment Epithelium

Abstract Autophagy is pivotal for cellular homeostasis and photoreceptor outer segment (POS) phagocytosis by the retinal pigment epithelium (RPE) in retinal degenerative diseases, such as age‐related macular degeneration and retinitis pigmentosa (RP). Yet, the mechanism of autophagy in the RPE remai...

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Autores principales:	Zhen Yi, Chaojuan Wen, Han Du, Yingwei Wang, Shuowei Chen, Jie Liu, Shuhan Zhang, Junwen Wang, Xueshan Xiao, Shiqiang Li, Xiaoyun Jia, Yi Jiang, Jiamin Ouyang, Panfeng Wang, James Fielding Hejtmancik, Wenmin Sun, Huangxuan Shen, Qingjiong Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-11-01
Colección:	Advanced Science
Materias:	autophagy neurodegeneration photoreceptor phagocytosis retinal pigment epithelium TRIM49
Acceso en línea:	https://doi.org/10.1002/advs.202512305
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