Synergistic Inhibition of Colorectal Cancer Growth by Combined PI3K and COX-2 Blockade in Cell Lines and Patient-Derived Organoids

<b>Background/Objectives:</b> PI3K/AKT/mTOR is a key pathway in cell proliferation, metabolism, and survival. Activating <i>PIK3CA</i> mutations are seen in up to 20% of colorectal cancers and are associated with increased cyclo-oxygenase-2 (COX-2) expression. Recent studies demonstrated a significa...

Descripció completa

Dades bibliogràfiques

Autors principals:	Emily Nghiem, Ariel Tzamarot, Terence Li, Zimo Huang, Mahshid Mohammadi, Dior Dedushi, Yvonne Saenger, Fernand Bteich, Chaoyuan Kuang
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2026-05-01
Col·lecció:	Pharmaceutics
Matèries:	colorectal cancer organoids celecoxib inavolisib PI3Kα COX-2
Accés en línia:	https://www.mdpi.com/1999-4923/18/6/683
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!