Synergistic Inhibition of Colorectal Cancer Growth by Combined PI3K and COX-2 Blockade in Cell Lines and Patient-Derived Organoids

<b>Background/Objectives:</b> PI3K/AKT/mTOR is a key pathway in cell proliferation, metabolism, and survival. Activating <i>PIK3CA</i> mutations are seen in up to 20% of colorectal cancers and are associated with increased cyclo-oxygenase-2 (COX-2) expression. Recent studies demonstrated a significa...

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Hlavní autoři:	Emily Nghiem, Ariel Tzamarot, Terence Li, Zimo Huang, Mahshid Mohammadi, Dior Dedushi, Yvonne Saenger, Fernand Bteich, Chaoyuan Kuang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2026-05-01
Edice:	Pharmaceutics
Témata:	colorectal cancer organoids celecoxib inavolisib PI3Kα COX-2
On-line přístup:	https://www.mdpi.com/1999-4923/18/6/683
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