Target-Based 6-5 Fused Ring Heterocyclic Scaffolds Display Broad Antiparasitic Potency In Vitro

Malaria, leishmaniasis, and African trypanosomiasis are protozoan diseases that constitute major global health problems, especially in developing countries; however, the development of drug resistance coupled with the toxicity of current treatments has hindered their management. The involvement of c...

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Autors principals:	Darline Dize, Mariscal Brice Tchatat Tali, Cyrille Armel Njanpa Ngansop, Rodrigue Keumoe, Eugenie Aimée Madiesse Kemgne, Lauve Rachel Tchokouaha Yamthe, Patrick Valere Tsouh Fokou, Boniface Pone Kamdem, Katsura Hata, Fabrice Fekam Boyom
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-02-01
Col·lecció:	Future Pharmacology
Matèries:	protozoan diseases drug repurposing cytotoxicity dihydrofolate reductase inhibitors potassium (K<sup>+</sup>) channel blocker ADME properties
Accés en línia:	https://www.mdpi.com/2673-9879/4/1/13
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