Anti-Shigella activity and killing kinetics of compounds from MMV Pathogen and COVID Boxes: Identifying leads against Shigellosis

Background: Shigellosis is a leading diarrheal disease, posing critical public health challenges in low- and middle-income countries. Rising antibiotic resistance exacerbates treatment limitations. Methods: We screened 560 compounds from the MMV Pathogen and COVID Boxes for in vitro activity against...

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Autori principali:	Lauve Rachel Tchokouaha Yamthe, Francine Kengne Mediesse, Yanick Kevin Melogmo Dongmo, Sonia Raissa Matchuenkam Gayap, Darline Dize, Patrick Valere Tsouh Fokou, Fabrice Fekam Boyom
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-01-01
Serie:	Current Research in Pharmacology and Drug Discovery
Soggetti:	Shigellosis Antibacterial agents Drug repurposing MMV Pathogen Box COVID Box Time-kill kinetics
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2590257126000027
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