Repair of naturally occurring mismatches can induce mutations in flanking DNA
‘Normal’ genomic DNA contains hundreds of mismatches that are generated daily by the spontaneous deamination of C (U/G) and methyl-C (T/G). Thus, a mutagenic effect of their repair could constitute a serious genetic burden. We show here that while mismatches introduced into human cells on an SV40-ba...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications Ltd
2014-04-01
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| Serie: | eLife |
| Soggetti: | |
| Accesso online: | https://elifesciences.org/articles/02001 |
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