The dual nature of mismatch repair as antimutator and mutator: for better or for worse

DNA is constantly under attack by a number of both exogenous and endogenous agents that challenge its integrity. Among the mechanisms that have evolved to counteract this deleterious action, mismatch repair (MMR) has specialized in removing DNA biosynthetic errors that occur when replicating the gen...

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Principais autores:	Sara Thornby Bak, Despoina eSakellariou, Javier ePena-Diaz
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2014-08-01
Series:	Frontiers in Genetics
Assuntos:	Neurodegenerative Diseases Trinucleotide Repeats Class switch recombination somatic hypermutation non-canonical mismatch repair antibody diversification
Acceso en liña:	http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00287/full
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