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Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice

We investigated whether cell proliferation and neurogenesis are altered in R6/2 transgenic Huntington's disease mice. Using bromodeoxyuridine (BrdU), we found a progressive decrease in the number of proliferating cells in the dentate gyrus of R6/2 mice. This reduction was detected in pre-symptomatic...

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Bibliografische Detailangaben
Hauptverfasser: Joana M.A.C. Gil, Paul Mohapel, Inês M. Araújo, Natalija Popovic, Jia-Yi Li, Patrik Brundin, Åsa Petersén
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2005-12-01
Schriftenreihe:Neurobiology of Disease
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Online-Zugang:http://www.sciencedirect.com/science/article/pii/S0969996105001452
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