De Novo Generation-Based Design of Potential Computational Hits Targeting the GluN1-GluN2A Receptor

Central nervous system (CNS) disorders such as depression severely impair human health. Targeted inhibition of the GluN1-GluN2A receptor is a promising therapeutic strategy, but current drugs often have adverse effects. To develop novel candidate drugs, this study utilized the (S)-ketamine and GluN1...

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主要な著者:	Yibo Liu, Zhijiang Yang, Yixuan Guo, Tengxin Huang, Li Pan, Junjie Ding, Weifu Dong
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-02-01
シリーズ:	Molecules
主題:	GluN1-GluN2A receptor antagonists de novo molecular generation virtual screening mechanism of action simulation organic synthesis electrophysiology
オンライン･アクセス:	https://www.mdpi.com/1420-3049/31/3/522
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