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Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans

Summary: Metabolic routing of nicotinamide (NAM) to NAD+ or 1-methylnicotinamide (MeNAM) has impacts on human health and aging. NAM is imported by cells or liberated from NAD+. The fate of 2H4-NAM in cultured cells, mice, and humans was determined by stable isotope tracing. 2H4-NAM is an NAD+ precur...

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Principais autores: Tumpa Dutta, Nidhi Kapoor, Meril Mathew, Suban S. Chakraborty, Nathan P. Ward, Nicolas Prieto-Farigua, Aimee Falzone, James P. DeLany, Steven R. Smith, Paul M. Coen, Gina M. DeNicola, Stephen J. Gardell
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-03-01
coleção:Cell Reports
Assuntos:
CP: Metabolism
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124723002292
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