Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

NRF2 is emerging as a major regulator of cellular metabolism. However, most studies have been performed in cancer cells, where co-occurring mutations and tumor selective pressures complicate the influence of NRF2 on metabolism. Here we use genetically engineered, non-transformed primary murine cells...

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Principais autores:	Yun Pyo Kang, Laura Torrente, Aimee Falzone, Cody M Elkins, Min Liu, John M Asara, Christian C Dibble, Gina M DeNicola
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2019-05-01
Serija:	eLife
Teme:	KEAP1 NRF2 CDO1 sulfite cysteine mouse model
Online dostop:	https://elifesciences.org/articles/45572
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