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SPAG17 mediates nuclear translocation of protamines during spermiogenesis

Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction and nuclear remodeling. Defects in protamination lead to increased DNA fragmentation and reduced male fertility. Since efficient sperm prod...

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Kaydedildi:
Asıl Yazarlar: Clara Agudo-Rios, Amber Rogers, Isaiah King, Virali Bhagat, Le My Tu Nguyen, Carlos Córdova-Fletes, Diego Krapf, Jerome F. Strauss, Lena Arévalo, Gina Esther Merges, Hubert Schorle, Eduardo R. S. Roldan, Maria Eugenia Teves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2023-09-01
Seri Bilgileri:Frontiers in Cell and Developmental Biology
Konular:
protamine
SPAG17
spermatogenesis
nucleocytoplasmic transport
spermiogenensis
Online Erişim:https://www.frontiersin.org/articles/10.3389/fcell.2023.1125096/full
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