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SPAG17 mediates nuclear translocation of protamines during spermiogenesis

Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction and nuclear remodeling. Defects in protamination lead to increased DNA fragmentation and reduced male fertility. Since efficient sperm prod...

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Guardado en:
Autores principales: Clara Agudo-Rios, Amber Rogers, Isaiah King, Virali Bhagat, Le My Tu Nguyen, Carlos Córdova-Fletes, Diego Krapf, Jerome F. Strauss, Lena Arévalo, Gina Esther Merges, Hubert Schorle, Eduardo R. S. Roldan, Maria Eugenia Teves
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2023-09-01
Colección:Frontiers in Cell and Developmental Biology
Materias:
protamine
SPAG17
spermatogenesis
nucleocytoplasmic transport
spermiogenensis
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fcell.2023.1125096/full
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