Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by t...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Taylor & Francis Group
2020-05-01
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| Seria: | Molecular & Cellular Oncology |
| Hasła przedmiotowe: | |
| Dostęp online: | http://dx.doi.org/10.1080/23723556.2020.1735284 |
| Etykiety: |
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