Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study

Abstract Background While the protective role of body mass index (BMI) in bone mass has been well-documented, the divergent associations between BMI and estimated bone mineral density (eBMD), attributed to its highly heterogeneous nature, remain insufficiently understood. Methods Leveraging the hith...

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Autors principals:	Xunying Zhao, Lin He, Xueyao Wu, Li Zhang, Jinyu Xiao, Changfeng Xiao, Yang Qu, Jingwei Zhu, Chenjiarui Qin, Deqin Huang, Pengyue Shen, Tao Han, Mengyu Fan, Jiayuan Li, Stephen Burgess, Xia Jiang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-05-01
Col·lecció:	BMC Medicine
Matèries:	Body mass index Estimated bone mineral density Mendelian randomization Divergent causal pathways Causal inference
Accés en línia:	https://doi.org/10.1186/s12916-025-04139-2
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