Causal plasma metabolites for breast cancer risk: a two-sample Mendelian randomization study with colocalization evidence

Abstract Background Breast cancer pathogenesis involves complex metabolic dysregulation, yet causal biomarkers remain elusive. This study aimed to assess causal effects of 1,400 human plasma metabolites on breast cancer (BC) risk using a two-sample Mendelian randomization (MR) framework. Methods We...

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Bibliografische Detailangaben

Hauptverfasser:	Hanghang Chen, Yueyuan Xu, Zepeng Wang, Xufeng Cheng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer 2025-10-01
Schriftenreihe:	Discover Oncology
Schlagworte:	Genome Wide Association Study (GWAS) Mendelian randomization (MR) Phenome-wide Mendelian randomization (PheWAS-MR) Colocalization Breast cancer (BC)
Online-Zugang:	https://doi.org/10.1007/s12672-025-03721-7
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