A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

The receptor-binding site (RBS) of influenza A viruses evolves to evade immune pressure, while maintaining efficient attachment to the host receptor. Wu et al. here identify the complex epistatic network in RBS of H3N2 viruses that limits reversibility of naturally occurring mutations to retain infe...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Nicholas C. Wu, Andrew J. Thompson, Jia Xie, Chih-Wei Lin, Corwin M. Nycholat, Xueyong Zhu, Richard A. Lerner, James C. Paulson, Ian A. Wilson
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2018-03-01
Цуврал:	Nature Communications
Онлайн хандалт:	https://doi.org/10.1038/s41467-018-03663-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!