A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

The receptor-binding site (RBS) of influenza A viruses evolves to evade immune pressure, while maintaining efficient attachment to the host receptor. Wu et al. here identify the complex epistatic network in RBS of H3N2 viruses that limits reversibility of naturally occurring mutations to retain infe...

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Principais autores:	Nicholas C. Wu, Andrew J. Thompson, Jia Xie, Chih-Wei Lin, Corwin M. Nycholat, Xueyong Zhu, Richard A. Lerner, James C. Paulson, Ian A. Wilson
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2018-03-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-018-03663-5
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