Enhancement of angiotensin II type 1 receptor-associated protein suppresses kidney inflammation in a mouse model of aristolochic acid nephropathy

Abstract Chronic kidney disease generally progresses to irreversible fibrosis through chronic inflammation and age-related changes. We had previously reported that genetic knockdown of angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP) exacerbates aging-associated kidney tubulointersti...

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Hlavní autoři:	Rika Furuta, Shingo Urate, Hiromichi Wakui, Tatsuki Uehara, Shunichiro Tsukamoto, Shinya Taguchi, Ryutaro Morita, Naohito Okami, Akio Yamashita, Kengo Azushima, Kouichi Tamura
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-07-01
Edice:	Scientific Reports
Témata:	Angiotensin II type 1 receptor-associated protein Anti-aging genes Aristolochic acid nephropathy Chronic kidney disease Renal fibrosis
On-line přístup:	https://doi.org/10.1038/s41598-025-08642-7
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