A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress

Abstract Pathological cardiac remodeling is a maladaptive response that leads to changes in the size, structure, and function of the heart. These changes occur due to an acute or chronic stress on the heart and involve a complex interplay of hemodynamic, neurohormonal and molecular factors. As a cri...

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Main Authors: Maja Bencun, Laura Spreyer, Etienne Boileau, Jessica Eschenbach, Norbert Frey, Christoph Dieterich, Mirko Völkers
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-01-01
Colecção:Scientific Reports
Assuntos:
Hypertrophic growth
Upstream open reading frame
Folliculin
Translation
TFEB
Lysosome
Acesso em linha:https://doi.org/10.1038/s41598-025-87107-3
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