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Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele

Abstract Background Facioscapulohumeral muscular dystrophy 1 (FSHD1) has an autosomal dominant pattern of inheritance and primarily affects skeletal muscle. The genetic cause of FSHD1 is contraction of the D4Z4 macrosatellite array on chromosome 4 alleles associated with a permissive haplotype causi...

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Principais autores: Premi Haynes, Karol Bomsztyk, Daniel G. Miller
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-08-01
Serier:Epigenetics & Chromatin
Fag:
FSHD
Facioscapulohumeral
Muscular
Dystrophy
DUX4
Epigenetics
Online adgang:http://link.springer.com/article/10.1186/s13072-018-0215-z
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