QR Code

Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary AtresiaResearch in Context

Summary: Background: Biliary atresia (BA) is the most prevalent serious neonatal biliary obstructive disorder and is a complex multifactorial liver disorder. Genome-wide association studies have identified Adducin 3 (ADD3) as a BA susceptibility gene but the mechanisms involved in disease causation...

Full description

Saved in:
Main Authors: Jerry LH. Ha, Yongqin Ye, Hailong Liu, Zhongluan Wu, Amy WY. Wai, Niwei Yan, Yim Cheung, Man-Ting So, Yuelan Zheng, Clara SM. Tang, Patrick HY. Chung, Kenneth KY. Wong, Paul KH. Tam, Vincent CH. Lui
Format: Artigo
Language:Inglês
Published: Elsevier 2025-12-01
Series:EBioMedicine
Subjects:
Biliary atresia
Genetic susceptibility
Adducin 3
Biliary damage
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425004967
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items