Loss of function of Adducin 3 (ADD3) causes abnormal development and impaired barrier function of human and mouse bile duct cells resulting in increased incidence and severity of Biliary AtresiaResearch in Context

Summary: Background: Biliary atresia (BA) is the most prevalent serious neonatal biliary obstructive disorder and is a complex multifactorial liver disorder. Genome-wide association studies have identified Adducin 3 (ADD3) as a BA susceptibility gene but the mechanisms involved in disease causation...

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Principais autores:	Jerry LH. Ha, Yongqin Ye, Hailong Liu, Zhongluan Wu, Amy WY. Wai, Niwei Yan, Yim Cheung, Man-Ting So, Yuelan Zheng, Clara SM. Tang, Patrick HY. Chung, Kenneth KY. Wong, Paul KH. Tam, Vincent CH. Lui
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-12-01
Serija:	EBioMedicine
Teme:	Biliary atresia Genetic susceptibility Adducin 3 Biliary damage
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2352396425004967
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